S-acetyl-PEG4-alcohol

Names

[ CAS No. ]:
223611-42-5

[ Name ]:
S-acetyl-PEG4-alcohol

[Synonym ]:
11-thioacetate-3,6,9-trioxa-undecan-1-ol
tetraethylene glycol monothioacetate
S-acetyl-PEG4-alcohol

Biological Activity

[Description]:

S-acetyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₂₀O₅S

[ Molecular Weight ]:
252.32800

[ Exact Mass ]:
252.10300

[ PSA ]:
90.29000

[ LogP ]:
0.30820

S-acetyl-PEG4-alcohol

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds