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(S,R,S)-AHPC-Me-C5-COOH

Names

[ CAS No. ]:
2229976-21-8

[ Name ]:
(S,R,S)-AHPC-Me-C5-COOH

Biological Activity

[Description]:

(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL


[In Vitro]

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) PROTAC degrader[1].

[References]

[1]. Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H42N4O6S

[ Molecular Weight ]:
586.74

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds