NG,NG-Dimethylarginine Dihydrochloride

Names

[ CAS No. ]:
220805-22-1

[ Name ]:
NG,NG-Dimethylarginine Dihydrochloride

[Synonym ]:
asym-Dimethylarginine ADMA
NG,NG-Dimethylarginine dihydrochloride
MFCD00270857
(Z)-N-[Amino(dimethylamino)methylene]-L-ornithine dihydrochloride
L-Ornithine, N-[amino(dimethylamino)methylene]-, (Z)-, hydrochloride (1:2)
NG,NG-DimethylarginineDihydrochloride
(2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid,dihydrochloride

Biological Activity

[Description]:

Asymmetric dimethylarginine dihydrochloride is an endogenous NO synthase inhibitor that reduces NO production, which contributes to endothelial dysfunction and cardiovascular disease[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[References]

[1]. Latika Sibal, et al. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90.

Chemical & Physical Properties

[ Boiling Point ]:
427.5ºC at 760 mmHg

[ Melting Point ]:
202-204OºC

[ Molecular Formula ]:
C₈H₂₀Cl₂N₄O₂

[ Molecular Weight ]:
275.18

[ Flash Point ]:
212.4ºC

[ Exact Mass ]:
274.096344

[ PSA ]:
102.44000

[ LogP ]:
2.05940

[ Vapour Pressure ]:
1.66E-08mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

J. Biol. Chem. 290 , 16723-43, (2015)

Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splic...

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.

Nat. Commun. 6 , 6428, (2015)

The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two splic...

Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.

Mol. Med. Report. 12 , 2253-62, (2015)

A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interactio...