KB-141

Names

[ CAS No. ]:
219691-94-8

[ Name ]:
KB-141

[Synonym ]:
Benzeneacetic acid, 3,5-dichloro-4-[4-hydroxy-3-(1-methylethyl)phenoxy]-
KB-141
3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid
[3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]acetic acid

Biological Activity

[Description]:

KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats.

[References]

References 1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. 2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302. 3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review. 4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8. View Related Products by Target Thyroid Hormone Receptor (THR)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
464.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆Cl₂O₄

[ Molecular Weight ]:
355.212

[ Flash Point ]:
234.9±28.7 °C

[ Exact Mass ]:
354.042572

[ LogP ]:
4.75

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds

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