Uridine 5'-diphosphate sodium salt

Names

[ CAS No. ]:
21931-53-3

[ Name ]:
Uridine 5'-diphosphate sodium salt

[Synonym ]:
Uridine, 5'-(trihydrogen diphosphate), sodium salt (1:2)
Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}uridine
trisodium,[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate
MFCD00006524
Uridine 5'-diphosphate sodium salt

Biological Activity

[Description]:

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2]. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2]. RT-PCR[2] Cell Line: Primary microglia Concentration: 100 μM Incubation Time: For 15 min Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.

[References]

[1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89.

[2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₄N₂O₁₂P_2.xNa

[ Molecular Weight ]:
448.125

[ Exact Mass ]:
447.966095

[ PSA ]:
243.12000

[ Appearance of Characters ]:
Powder | White

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: soluble100 mg/mL, clear, colorless to very faintly yellow | Soluble in water to 100mM

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H371

[ Precautionary Statements ]:
P260

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22;R48/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Preparation

Articles

Enzyme-histochemical demonstration of microglial cells in the adult and postnatal rabbit retina.

J. Comp. Neurol. 282(2) , 249-63, (1989)

Enzyme-histochemical methods for thiamine pyrophosphatase (TPPase) and nucleoside diphosphatase (NDPase) were applied to wholemounted rabbit retinae to demonstrate the shape and distribution of microg...

P2X2 receptor mediates stimulation of parasensory cation absorption by cochlear outer sulcus cells and vestibular transitional cells.

J. Neurosci. 21(23) , 9168-74, (2001)

Cochlear outer sulcus cells (OSC) and vestibular transitional cells (VTC) are part of the parasensory epithelium in the inner ear and are located in homologous positions between the sensory hair cells...