Z-Ala-Pro-Phe-chloromethylketone

Names

[ Name ]:
Z-Ala-Pro-Phe-chloromethylketone

[Synonym ]:
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-
N-[(Benzyloxy)carbonyl]-L-alanyl-N-[(2S)-4-chloro-3-oxo-1-phenyl-2-butanyl]-L-prolinamide

Biological Activity

[Description]:

Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Zhang D, et al. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5746-51.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
754.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₀ClN₃O₅

[ Molecular Weight ]:
499.987

[ Flash Point ]:
410.3±32.9 °C

[ Exact Mass ]:
499.187408

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.581

Z-Ala-Pro-Phe-chloromethylketone

Names

Biological Activity

Chemical & Physical Properties

Related Compounds