<Suppliers Price>

RIPK1-IN-12

Names

[ CAS No. ]:
2173556-92-6

[ Name ]:
RIPK1-IN-12

Biological Activity

[Description]:

RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase
Research Areas >> Inflammation/Immunology

[Target]

RIPK1[1]


[In Vitro]

RIPK1-IN-12 (Compound 58; 24 hours) demonstrates potent anti-necroptotic activity (EC50=1.6 nM in HT-29 cells and EC50= 2.9 nM in L929 cells)[1].

[References]

[1]. Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H26N4O3S

[ Molecular Weight ]:
450.55

Related Compounds