2'-O-Methylguanosine

Names

[ Name ]:
2'-O-Methylguanosine

[Synonym ]:
Guanosine, 2'-O-methyl-
2'-methylguanosine
Gm19
2'-O-(TERT-BUTYLDIMETHYLSILYL)PACLITAXEL
UNII-W722H4PA1S
2'-O-Methylguanosine
Guanosine,2'-O-methyl
2'-O-Methyl Guanosine
2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one
MFCD00057053
O2'-methyl-guanosine
2'-O-methyl-guanosine
2’-OMeGuanosine
2'-O-Methylguanosine Hydrate

Biological Activity

[Description]:

2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Metabolic Disease

[References]

[1]. B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25(20):4093-7.

[2]. T Mori, et al. Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line. Biochem Biophys Res Commun. 1998 Oct 20;251(2):416-22.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
711.7ºC at 760 mmHg

[ Melting Point ]:
218-220ºC

[ Molecular Formula ]:
C₁₁H₁₅N₅O₅

[ Molecular Weight ]:
297.267

[ Flash Point ]:
384.2ºC

[ Exact Mass ]:
297.107330

[ PSA ]:
148.51000

[ LogP ]:
-0.36

[ Vapour Pressure ]:
2.93E-21mmHg at 25°C

[ Index of Refraction ]:
1.829

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%