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Mal-PEG2-VCP-Eribulin

Names

[ CAS No. ]:
2130869-18-8

[ Name ]:
Mal-PEG2-VCP-Eribulin

Biological Activity

[Description]:

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[References]

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

[2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.

Chemical & Physical Properties

[ Molecular Formula ]:
C70H99N7O21

[ Molecular Weight ]:
1374.57

Related Compounds