Propargyl-PEG10-amine

Names

[ CAS No. ]:
2112737-25-2

[ Name ]:
Propargyl-PEG10-amine

Biological Activity

[Description]:

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₄₅NO₁₀

[ Molecular Weight ]:
495.60

[ Storage condition ]:
2-8°C

Related Compounds

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