Propargyl-PEG10-Boc

Names

[ CAS No. ]:
2055022-22-3

[ Name ]:
Propargyl-PEG10-Boc

[Synonym ]:
2-Methyl-2-propanyl 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacont-33-yn-1-oate
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-yn-1-oic acid, 1,1-dimethylethyl ester
MFCD28976692

Biological Activity

[Description]:

Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
592.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₅₂O₁₂

[ Molecular Weight ]:
580.705

[ Flash Point ]:
242.5±28.8 °C

[ Exact Mass ]:
580.345886

[ LogP ]:
-1.26

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.462

Related Compounds

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