Thalidomide-NH-C6-NH2 TFA

Names

[ CAS No. ]:
2093386-51-5

[ Name ]:
Thalidomide-NH-C6-NH2 TFA

Biological Activity

[Description]:

Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅F₃N₄O₆

[ Molecular Weight ]:
486.44

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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