Axl-IN-21

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.

References 1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer)