Quinine hemisulfate hydrate

Names

[ CAS No. ]:
207671-44-1

[ Name ]:
Quinine hemisulfate hydrate

[Synonym ]:
Quinine hemisulfate
Quinine sulfate

Biological Activity

[Description]:

Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: Parasite[1], 169 μM (mSlo3)[2]

[References]

[1]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144.

[2]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O

[ Molecular Weight ]:
782.94300

[ Exact Mass ]:
782.35600

[ PSA ]:
192.62000

[ LogP ]:
6.52160

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Interaction of quinine sulfate with anionic micelles of sodium dodecylsulfate: A time-resolved fluorescence spectroscopy at different pH.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 148 , 49-59, (2015)

Photophysical behavior and rotational relaxation dynamics of quinine sulfate (QS) in anionic surfactant, sodium dodecylsulfate (SDS) at different pH have been studied using steady state and time resol...

The uptake of trehalose glycolipids by macrophages is independent of Mincle.

ChemBioChem. 16(4) , 683-93, (2015)

Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms throu...

In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.

Antimicrob. Agents Chemother. 59 , 3271-80, (2015)

4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stabilit...

Related Compounds

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