L-Cysteinesulfinic acid monohydrate

Names

[ CAS No. ]:
207121-48-0

[ Name ]:
L-Cysteinesulfinic acid monohydrate

[Synonym ]:
MFCD00150732
EINECS 214-228-5
L-cysteinesulfinic acid monohydrate

Biological Activity

[Description]:

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR1:3.92 (pEC50)

mGluR2:3.9 (pEC50)

mGluR4:2.7 (pEC50)

mGluR5:4.6 (pEC50)

mGluR6:4.0 (pEC50)

mGluR8:3.94 (pEC50)

[In Vitro]

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].

[References]

[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.

[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.

Chemical & Physical Properties

[ Boiling Point ]:
580.6ºC at 760 mmHg

[ Melting Point ]:
163ºC (dec.)(lit.)

[ Molecular Formula ]:
C₃H₉NO₅S

[ Molecular Weight ]:
171.17200

[ Flash Point ]:
304.9ºC

[ Exact Mass ]:
171.02000

[ PSA ]:
129.06000

[ LogP ]:
0.12170

[ Vapour Pressure ]:
2.73E-15mmHg at 25°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system.

Prog. Neurobiol. 35 , 313, (1990)