Luteolin 7-rutinoside

Names

[ CAS No. ]:
20633-84-5

[ Name ]:
Luteolin 7-rutinoside

[Synonym ]:
2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5-hydroxy-
MFCD03792755

Biological Activity

[Description]:

Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Infection

Natural Products >> Flavonoids

Research Areas >> Inflammation/Immunology

[In Vitro]

At a dose of 10 μg Luteolin-7-rutinoside (lonicerin)/mL, there is an approximately 47% decrease of the proliferation as compared to proliferation of Luteolin-7-rutinoside treated (control) T cells (p<0.05). Luteolin-7-rutinoside at 40 μg/mL dose give almost the same rate of T cell proliferation as does 20 μg/mL dose of Luteolin-7-rutinoside. The suppressive activity is dose dependent. Luteolin-7-rutinoside treatment swifts Th1-Th2 balance away from Th1-toward Th2-type responses. Luteolin-7-rutinoside inhibits nitric oxide (NO) production from macrophages[1].

[References]

[1]. Lee JH, et al. Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Arch Pharm Res. 2011 May;34(5):853-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
954.0±65.0 °C at 760 mmHg

[ Melting Point ]:
192-196 °C

[ Molecular Formula ]:
C₂₇H₃₀O₁₅

[ Molecular Weight ]:
594.518

[ Flash Point ]:
316.9±27.8 °C

[ Exact Mass ]:
594.158447

[ LogP ]:
1.35

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.747

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Antitcoagulant and antiplatelet activities of scolymoside.

BMB Rep. 48 , 577-82, (2015)

Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. Here, the anticoagulant effects of scolymoside, an active compound in C. subternata, were examined by mo...