Capsiate

Names

[ CAS No. ]:
205687-01-0

[ Name ]:
Capsiate

[Synonym ]:
Capsiate Natura
UNII-PX8I7HG5I3
capsiate

Biological Activity

[Description]:

Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[Target]

TRPV1

[In Vitro]

Capsiate evokes current responses in HEK293 cells expressing TRPV1[1].

[In Vivo]

Capsiate does not exhibit irritancy-related effects on the oral cavity or eye[1]. Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice[1]. Animal Model: Male ddY-strain mice (20–24 g) [1] Dosage: 0.5 or 5 mM Administration: P.o. Result: Did not cause pungency-related behaviors.

[References]

[1]. Iida T, et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 2003;44(7):958-967.

Chemical & Physical Properties

[ Boiling Point ]:
421.3±40.0 °C(Predicted)

[ Molecular Formula ]:
C₁₈H₂₆O₄

[ Molecular Weight ]:
306.39700

[ Exact Mass ]:
306.18300

[ PSA ]:
55.76000

[ LogP ]:
4.21660

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.