LAU159

Names

[ CAS No. ]:
2055050-87-6

[ Name ]:
LAU159

[Synonym ]:
8-Chloro-2-(3-methoxyphenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

Biological Activity

[Description]:

LAU159 is a functionally selective positive modulator of α1β3 GABA(A) receptor with an EC50 of 2.2 μM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

EC50: 2.2 μM (α1β3 GABA(A) receptor)[1]

[References]

[1]. Varagic Z, et al. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. Br J Pharmacol. 2013 May;169(2):371-83.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
473.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂ClN₃O₂

[ Molecular Weight ]:
325.749

[ Flash Point ]:
240.3±31.5 °C

[ Exact Mass ]:
325.061798

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.706

Related Compounds

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