2(1H)-Quinolinone,7-hydroxy-4-methyl-

Names

[ CAS No. ]:
20513-71-7

[ Name ]:
2(1H)-Quinolinone,7-hydroxy-4-methyl-

[Synonym ]:
7-hydroxy-4-methyl-1H-quinolin-2-one
2,7-Dihydroxy-4-methylquinoline 7-Hydroxy-4-methylcarbostyryl

Biological Activity

[Description]:

7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Tang VJ, et al. DNA Binding Hydroxyl Radical Probes. Radiat Phys Chem Oxf Engl 1993. 2012 Jan;81(1):46-51.

Chemical & Physical Properties

[ Density]:
1.264 g/cm3

[ Boiling Point ]:
417.8ºC at 760 mmHg

[ Melting Point ]:
≥250ºC(lit.)

[ Molecular Formula ]:
C₁₀H₉NO₂

[ Molecular Weight ]:
175.18400

[ Flash Point ]:
206.5ºC

[ Exact Mass ]:
175.06300

[ PSA ]:
53.09000

[ LogP ]:
1.54210

[ Vapour Pressure ]:
1.42E-07mmHg at 25°C

[ Index of Refraction ]:
1.611

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

On the metabolism of quinoline and isoquinoline: possible molecular basis for differences in biological activities.

Carcinogenesis 4 , 1169-1173, (1983)

Quinoline is a hepatocarcinogen in mice and rats, a mutagen in Salmonella typhimurium, and induces unscheduled DNA synthesis in primary cultures of rat hepatocytes. In contrast, isoquinoline has not b...

Microbial metabolism of quinoline and related compounds. XIX. Degradation of 4-methylquinoline and quinoline by Pseudomonas putida K1.

Biol. Chem. Hoppe-Seyler 374 , 479-488, (1993)

A bacterial strain, designated K1, which utilizes 4-methylquinoline and quinoline as sole source of carbon, nitrogen and energy was isolated from soil. Based on its morphological and physiological cha...

Related Compounds

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