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AZ 13705339

Names

[ CAS No. ]:
2016806-57-6

[ Name ]:
AZ 13705339

[Synonym ]:
Benzonitrile, 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]-
2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile

Biological Activity

[Description]:

AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4; inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 59 nM.

[References]

References 1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. View Related Products by Target p21-activated Kinase (PAK)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
868.7±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C33H36FN7O3S

[ Molecular Weight ]:
629.747

[ Flash Point ]:
479.2±37.1 °C

[ Exact Mass ]:
629.258423

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.682

Related Compounds