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Ferrous bisglycinate

Names

[ CAS No. ]:
20150-34-9

[ Name ]:
Ferrous bisglycinate

[Synonym ]:
Iron protochloride
Natural lawrencite
Ferro 66
ferrous bisglycinate
ferrous glycinate
FERROUS CHLORIDE
FeCl2
iron dichloride
ferrous dichloride

Biological Activity

[Description]:

Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[In Vitro]

Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability[2]. Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells[2]. Cell Viability Assay[2] Cell Line: Caco-2 cells Concentration: 0, 25, 50, 100, 200 μM Incubation Time: 2 hours Result: Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells. Western Blot Analysis[2] Cell Line: Caco-2 cells Concentration: 25 μM Incubation Time: 2 hours Result: Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells.

[In Vivo]

Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice[3]. Animal Model: Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)[3] Dosage: 500 mg/kg iron Administration: P.o. (add to the diet) for 10 days Result: Had the best survival rates (100%). Caused the least body lost (9% body loss).

[References]

[1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8.

[2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485.

[3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766.

Chemical & Physical Properties

[ Boiling Point ]:
240.9ºC at 760 mmHg

[ Molecular Formula ]:
C4H8FeN2O4

[ Molecular Weight ]:
203.962

[ Exact Mass ]:
203.983353

[ PSA ]:
132.30000

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds