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MMSET-IN-1

Names

[ CAS No. ]:
1998139-29-9

[ Name ]:
MMSET-IN-1

Biological Activity

[Description]:

MMSET-IN-1 is a multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) inhibitor against SETD2 and MMSET with IC50s of 0.49 and 3.3 μM, respectively. MMSET-IN-1 has a Kd of 1.6 μM for MMSET[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.49 μM (SETD2), 3.3 μM (MMSET)[1] Kd: 1.6 μM[1]


[References]

[1]. Tisi D, et al. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H29N7O5

[ Molecular Weight ]:
423.47

Related Compounds