Amylin (1-13) (human)

Names

[ CAS No. ]:
198328-30-2

[ Name ]:
Amylin (1-13) (human)

[Synonym ]:
H-LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-OH
Islet AMyloid Polypeptide (1-13) (huMan),DAP (1-13) (huMan),InsulinoMa AMyloid Peptide (1-13) (huMan),Diabetes-Associated Peptide (1-13) (huMan)
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA
AMYLIN (1-13) (HUMAN)
H-LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-OH (DISULFIDE BRIDGE: 2-7)
AMylin (1-13) (huMan) Islet AMyloid Polypeptide (1-13) (huMan),DAP (1-13) (huMan),InsulinoMa AMyloid Peptide (1-13) (huMan),Diabetes-Associated Peptide (1-13) (huMan)
H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-OH,(Disulfide bond)
KCNTATCATQRLA (DISULFIDE BRIDGE: 2-7)
Biotinyl-Neurokinin b,Biotinyl-NeuroMedin K,Biotinyl-NKB
ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-ARG-SER-SER-ASN-ASN-LEU-GLY-PRO-VAL-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2: ATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA (DISULFIDE BRIDGE:CYS2-CYS7)
KCNTATCATQRLA(Disulfidebridge:2-7)

Biological Activity

[Description]:

Amylin (1-13) (human) is a fragment and a residues within amyloid cores of Amylin (human IAPP). Amylin is a glucose-regulating hormone, deposits as amyloid fibrils in condition of type II diabetes (T2D). Amylin (1-13) (human) has no effect on firbl formation, as it cannot form fibrils by itself[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Cao Q, et al. Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat Struct Mol Biol. 2020 Jul;27(7):653-659.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₄H₉₅N₁₉O₁₉S₂

[ Molecular Weight ]:
1378.58

[ Exact Mass ]:
1377.65000

[ PSA ]:
697.91000

Related Compounds

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