JAK1-IN-8

Names

[ CAS No. ]:
1973485-18-5

[ Name ]:
JAK1-IN-8

[Synonym ]:
N-(5-{4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl}imidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide
MFCD30530428
Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-

Biological Activity

[Description]:

JAK1-IN-8, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

JAK1:<500 nM (IC50)

JAK2:500-1000 nM (IC50)

JAK3:>5000 nM (IC50)

[References]

[1]. Jin Li, et al. Composés d'imidazo[1,2-a]pyridin-2-ylamine substitués, compositions pharmaceutiques et leurs méthodes d'utilisation. Patent WO2016119700A1.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₂₃FN₄O₃S

[ Molecular Weight ]:
442.51

[ Exact Mass ]:
442.147491

[ LogP ]:
1.05

[ Index of Refraction ]:
1.712

Related Compounds

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