RG-101

Names

[ CAS No. ]:
1929655-04-8

[ Name ]:
RG-101

Biological Activity

[Description]:

RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA

Research Areas >> Infection

[In Vitro]

RG-101 is a mixed chemistry phosphorothioate oligonucleotide inhibitor of miR-122 that is linked to a multivalent N-acetylgalactosamine carbohydrate structure designed to enhance uptake of the oligonucleotide by hepatocytes through binding to the asialoglycoprotein receptor on hepatocytes[1].

[References]

[1]. Meike H van der Ree, et al. Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial. Lancet. 2017 Feb 18;389(10070):709-717.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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