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1929655-04-8

1929655-04-8 structure
1929655-04-8 structure
  • Name: RG-101
  • Chemical Name: RG-101
  • CAS Number: 1929655-04-8
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Epigenetics MicroRNA
  • Create Date: 2021-12-26 19:55:10
  • Modify Date: 2024-01-10 17:00:31
  • RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication[1].

Name RG-101
Description RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication[1].
Related Catalog
In Vitro RG-101 is a mixed chemistry phosphorothioate oligonucleotide inhibitor of miR-122 that is linked to a multivalent N-acetylgalactosamine carbohydrate structure designed to enhance uptake of the oligonucleotide by hepatocytes through binding to the asialoglycoprotein receptor on hepatocytes[1].
References

[1]. Meike H van der Ree, et al. Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial. Lancet. 2017 Feb 18;389(10070):709-717.

No Any Chemical & Physical Properties