Pomalidomide
Names
[ CAS No. ]:
19171-19-8
[ Name ]:
Pomalidomide
[Synonym ]:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
Pomalidomide
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
Pomalyst
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
CC-4047
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 13 nM (TNF-α, in PBMCs)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
582.9±45.0 °C at 760 mmHg
[ Melting Point ]:
318.5 - 320.5°
[ Molecular Formula ]:
C13H11N3O4
[ Molecular Weight ]:
273.244
[ Flash Point ]:
306.3±28.7 °C
[ Exact Mass ]:
273.074951
[ PSA ]:
109.57000
[ LogP ]:
-0.74
[ Appearance of Characters ]:
yellow
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.691
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: ≥14mg/mL
MSDS
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
NR3397905
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Blood Cancer J. 5 , e312, (2015)
Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IR...
Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.J. Clin. Pharmacol. 55(2) , 168-78, (2015)
Pomalidomide offers an alternative for patients with relapsed/refractory multiple myeloma who have exhausted treatment options with lenalidomide and bortezomib. Little is known about pomalidomide's po...
A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma.J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 76-82, (2015)
In this study, a sensitive UPLC-MS/MS assay was developed and validated for high-throughput determination of pomalidomide in rat plasma using celecoxib as an internal standard (IS). Liquid liquid extr...