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Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)

Names

[ CAS No. ]:
191338-87-1

[ Name ]:
Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)

[Synonym ]:
ACETYL-GLU-SER-MET-ASPARTINAL
AC-ESMD-ALDEHYDE
N-ACETYL-GLU-SER-MET-ASPARTINAL
AC-GLU-SER-MET-ASP-CHO
L-Methioninamide, N-acetyl-L-α-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]-
Acetyl-glutamyl-serinyl-methionyl-aspartal
N-Acetyl-L-α-glutamyl-L-seryl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-methioninamide
AC-GLU-SER-MET-ASP-ALDEHYDE

Biological Activity

[Description]:

Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[References]

[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.  

[2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1049.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H30N4O10S

[ Molecular Weight ]:
506.527

[ Flash Point ]:
588.6±34.3 °C

[ Exact Mass ]:
506.168274

[ PSA ]:
253.60000

[ LogP ]:
-1.68

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.555

Safety Information

[ WGK Germany ]:
3

Related Compounds