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CP-101606 mesylate

Names

[ CAS No. ]:
188591-67-5

[ Name ]:
CP-101606 mesylate

[Synonym ]:
UNII-I23V4CCC9V
Traxoprodil mesylate

Biological Activity

[Description]:

Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45.  

[2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14.  

[3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H29NO6S

[ Molecular Weight ]:
423.52

[ Exact Mass ]:
423.17200

[ PSA ]:
126.68000

[ LogP ]:
3.32040

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319-H400

[ Precautionary Statements ]:
P273-P301 + P310 + P330-P305 + P351 + P338-P391

[ Hazard Codes ]:
T

[ RIDADR ]:
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

Related Compounds