YIR-819 TFA salt
Names
[ CAS No. ]:
1883372-87-9
[ Name ]:
YIR-819 TFA salt
Biological Activity
[Description]:
YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM); A useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.
[References]
References 1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6. 2. Boonstra A, et al. Antivir Ther. 2012;17(4):657-67. View Related Products by Target HIV
Chemical & Physical Properties
[ Molecular Formula ]:
C25H35ClF3N7O5
[ Molecular Weight ]:
606.044