PCSK9 modulator 10

Names

[ Name ]:
PCSK9 modulator 10

Biological Activity

[Description]:

PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM; significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.

[References]

References 1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3. View Related Products by Target PCSK9

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₆ClF₆NO

[ Molecular Weight ]:
365.659

Related Compounds

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