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ML 10302 hydrochloride

Names

[ CAS No. ]:
186826-17-5

[ Name ]:
ML 10302 hydrochloride

Biological Activity

[Description]:

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM。ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT4 Receptor:4 nM (EC50)


[In Vitro]

ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].

[References]

[1]. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.

[2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H22Cl2N2O3

[ Molecular Weight ]:
349.25300

[ Exact Mass ]:
348.10100

[ PSA ]:
64.79000

[ LogP ]:
3.89460

Related Compounds