Chimmitecan

Names

[ Name ]:
Chimmitecan

[Synonym ]:
(S)-9-Allyl-10-hydroxycamptothecin
UNII-889O97XDAD
Chimmitecan

Biological Activity

[Description]:

Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13(4):1298-307.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀N₂O₅

[ Molecular Weight ]:
404.42

[ Exact Mass ]:
404.13700

[ PSA ]:
101.65000

[ LogP ]:
2.51370