<Suppliers Price>

PI3K/mTOR Inhibitor-2

Names

[ CAS No. ]:
1848242-58-9

[ Name ]:
PI3K/mTOR Inhibitor-2

Biological Activity

[Description]:

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:3.4 nM (IC50)

PI3Kβ:34 nM (IC50)

PI3Kδ:16 nM (IC50)

PI3Kγ:1 nM (IC50)

mTOR:4.7 nM (IC50)


[In Vitro]

PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively[1].

[References]

[1]. Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H13ClF2N4O4S

[ Molecular Weight ]:
478.86

Related Compounds