Acid-PEG4-C2-Boc

Names

[ Name ]:
Acid-PEG4-C2-Boc

[Synonym ]:
MFCD28096679
Bis(2-methyl-2-propanyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(1,1-dimethylethyl) ester

Biological Activity

[Description]:

Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Jennifer PITZEN , et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
452.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₀O₈

[ Molecular Weight ]:
406.511

[ Flash Point ]:
191.1±26.0 °C

[ Exact Mass ]:
406.256653

[ LogP ]:
1.84

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.450

[ Storage condition ]:
2-8°C

Related Compounds

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