Trityl-PEG8-azide

Names

[ Name ]:
Trityl-PEG8-azide

[Synonym ]:
25-Azido-1,1,1-triphenyl-2,5,8,11,14,17,20,23-octaoxapentacosane
MFCD22683296
2,5,8,11,14,17,20,23-Octaoxapentacosane, 25-azido-1,1,1-triphenyl-

Biological Activity

[Description]:

Trityl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₇N₃O₈

[ Molecular Weight ]:
637.763

[ Exact Mass ]:
637.336304

[ LogP ]:
3.90

Related Compounds

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