Picoplatin

Names

[ Name ]:
Picoplatin

[Synonym ]:
Platinum(2+) chloride - 2-methylpyridine ammoniate (1:2:1:1)
Picoplatin
cis-amminedichloro(2-methylpyridine)platinum(II)
cis-amminedichlorido(2-methylpyridine)platinum(II)
cis-amminedichloro(2-picoline)platinum(II)
Pyridine, 2-methyl-, platinum(2+) salt, hydrochloride, ammoniate (1:1:2:1)
ZD 0473
Picoplatin [INN:BAN]
(SP-4-3)-Amminedichloro(2-methylpyridine)platinium
AMD 473
cis-PtCl2(NH3)(2-picoline)

Biological Activity

[Description]:

Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. J Holford, et al. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br J Cancer. 1998;77(3):366-73.

Chemical & Physical Properties

[ Boiling Point ]:
127.5ºC at 760mmHg

[ Molecular Formula ]:
C₆H₇Cl₂NPt

[ Molecular Weight ]:
376.147

[ Flash Point ]:
26.1ºC

[ Exact Mass ]:
374.986908

[ PSA ]:
12.89000

[ LogP ]:
2.76650

[ Vapour Pressure ]:
13.5mmHg at 25°C

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Related Compounds

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