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MM-206

Names

[ CAS No. ]:
1809581-87-0

[ Name ]:
MM-206

[Synonym ]:
MFCD30179936
Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-[4-hydroxy-3-(phenylthio)-1-naphthalenyl]-
2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide
2,3,4,5,6-Pentafluoro-N-[4-hydroxy-3-(phenylsulfanyl)-1-naphthyl]benzenesulfonamide
MM 206
MM-206

Biological Activity

[Description]:

A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD); also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM,

[References]

References 1. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. View Related Products by Target STAT

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
601.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H12F5NO3S2

[ Molecular Weight ]:
497.458

[ Flash Point ]:
317.8±34.3 °C

[ Exact Mass ]:
497.017883

[ LogP ]:
5.81

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.694

Related Compounds