Hydroxy-PEG4-O-Boc

Names

[ Name ]:
Hydroxy-PEG4-O-Boc

[Synonym ]:
MFCD27977509
3,6,9,12,15-Pentaoxaheptadecan-1-oic acid, 17-hydroxy-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate

Biological Activity

[Description]:

Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
432.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₂O₈

[ Molecular Weight ]:
352.421

[ Flash Point ]:
142.6±20.8 °C

[ Exact Mass ]:
352.209717

[ LogP ]:
-0.60

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.454

Hydroxy-PEG4-O-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds