KL-1333(NQO1 activator 1)
Names
[ CAS No. ]:
1800405-30-4
[ Name ]:
KL-1333(NQO1 activator 1)
Biological Activity
[Description]:
NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1].
[Related Catalog]:
[Target]
NQO1[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C14H12N2O2
[ Molecular Weight ]:
240.26