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KL-1333(NQO1 activator 1)

Names

[ CAS No. ]:
1800405-30-4

[ Name ]:
KL-1333(NQO1 activator 1)

Biological Activity

[Description]:

NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

NQO1[1]


[References]

[1]. Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H12N2O2

[ Molecular Weight ]:
240.26


Related Compounds