XR 5118

Names

[ Name ]:
XR 5118

Biological Activity

[Description]:

XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued

[References]

References 1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21. 2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32. 3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1) Thrombosis

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂ClN₃O₂S₂

[ Molecular Weight ]:
435.985

Related Compounds

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