Obtusifoliol

Names

[ Name ]:
Obtusifoliol

[Synonym ]:
4alpha,14alpha-Dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
(3S,4S,5S,10S,13R,14R,17R)-4,10,13,14-tetramethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,4,5,6,7,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol
4alpha,14alpha-Dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol
EECD77B7-C927-4E6E-B634-DEDFB042A6B9
methylsterol
Obtusifoliol

Biological Activity

[Description]:

Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[In Vitro]

Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1]. Cell Viability Assay[2] Cell Line: MCF-7; MDA-MB231 breast cancer cells Concentration: 0.1, 1, 10, 40, 80, and 100 µM Incubation Time: 48 hours Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.

[References]

[1]. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99.

[2]. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.

Chemical & Physical Properties

[ Density]:
0.98g/cm3

[ Boiling Point ]:
501.3ºC at 760mmHg

[ Molecular Formula ]:
C₃₀H₅₀O

[ Molecular Weight ]:
426.71700

[ Flash Point ]:
221.9ºC

[ Exact Mass ]:
426.38600

[ PSA ]:
20.23000

[ LogP ]:
8.33500

[ Vapour Pressure ]:
3.77E-12mmHg at 25°C

[ Index of Refraction ]:
1.525

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.