oxymatrine
Names
[ CAS No. ]:
16837-52-8
[ Name ]:
oxymatrine
[Synonym ]:
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]naphthyridin-10-one 4-oxide
(4R,7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]naphthyridin-10-one 4-oxide
Ammothamnine
Matrine N-oxide
(7aS,13aR,13bR,13cS)Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (7aS,13aR,13bR,13cS)-
Oxymatrine
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H24N2O2
[ Molecular Weight ]:
264.363
[ Exact Mass ]:
264.183777
[ PSA ]:
49.74000
[ LogP ]:
-0.35
[ Appearance of Characters ]:
white to off-white
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.637
[ Water Solubility ]:
methanol: soluble10mg/mL, clear, colorless
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OQ1770000
- CHEMICAL NAME :
- Matrine, 1-oxide
- CAS REGISTRY NUMBER :
- 16837-52-8
- LAST UPDATED :
- 199412
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C15-H24-N2-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 521 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18(7),23,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 18,2555,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 257 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-20/22
[ Safety Phrases ]:
24/25
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
OQ1770000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Cancer Chemother. Pharmacol. 75(2) , 353-63, (2015)
Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of the quinolizidine alkaloid compounds extracted from the root of Sophora flavescens (a traditional Chinese herb). Oxymatrine has b...
Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.Biochem. Pharmacol. 84(6) , 830-7, (2012)
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of ...
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.CNS Neurosci. Ther. 18(12) , 1030-2, (2012)