BMT-124110

Names

[ Name ]:
BMT-124110

Biological Activity

[Description]:

BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1[1].

[In Vivo]

BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1].

[References]

[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₇N₃O₃

[ Molecular Weight ]:
369.46

Related Compounds

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