<Suppliers Price>

AF 64394

Names

[ CAS No. ]:
1637300-25-4

[ Name ]:
AF 64394

[Synonym ]:
N-(4-Chloro-2-isopropoxybenzyl)-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-

Biological Activity

[Description]:

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others

[Target]

pIC50: 7.3 (GPR3)[1].


[In Vitro]

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization[1].

[References]

[1]. Jensen T, et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C21H20ClN5O

[ Molecular Weight ]:
393.869

[ Exact Mass ]:
393.135651

[ LogP ]:
4.65

[ Index of Refraction ]:
1.661

[ Storage condition ]:
2-8℃

Related Compounds