UCM-1336

Names

[ Name ]:
UCM-1336

Biological Activity

[Description]:

UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[Target]

IC50: 2 μM (2 μM)[1].

[References]

[1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₇N₃O₂

[ Molecular Weight ]:
423.59

Related Compounds

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