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Teneligliptin hydrobromide hydrate

Names

[ CAS No. ]:
1572583-29-9

[ Name ]:
Teneligliptin hydrobromide hydrate

[Synonym ]:
Teneligliptin sesquihydrobromide hydrate
Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-, hydrobromide, hydrate (2:5:1)
{(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl}(1,3-thiazolidin-3-yl)methanone hydrobromide hydrate (2:5:1)

Biological Activity

[Description]:

Teneligliptin hydrobromide hydrate is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Research Areas >> Metabolic Disease

[References]

[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H30N6OS

[ Molecular Weight ]:
1275.731

[ Exact Mass ]:
1270.081665

[ Storage condition ]:
2-8℃

Related Compounds