PSB 1115

Names

[ Name ]:
PSB 1115

[Synonym ]:
Tocris-2009

Biological Activity

[Description]:

PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

A2BR

[In Vitro]

PSB-1115 (100 μM) 在回肠/空肠段中抑制 TNBS (10 mM) 诱导的 ACh 收缩抑制现象[1]。

[In Vivo]

PSB-1115 (0.5 mg/kg; i.p.; single dose, 20 min before the inhalation) antagonizes the inhibitory effect of non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2].

[References]

[1]. Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₄N₄O₅S

[ Molecular Weight ]:
350.35000

[ Exact Mass ]:
350.06800

[ PSA ]:
146.29000

[ LogP ]:
1.81740

[ Storage condition ]:
-20°C

PSB 1115

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds