UCM 608

Names

[ Name ]:
UCM 608

[Synonym ]:
Carcinine ditrifluoroacetate
2-PHENYLMELATONIN
Tocris-0680
HMS3266J05

Biological Activity

[Description]:

UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor

Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

pKi: 10.7 (MT1)[1]. pKi: 10.4 (MT2)[1]

[In Vitro]

UCM 608 is a high affinity melatonin membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4 [1].

[References]

[1]. Radogna F, et al. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009;239(1):37-45.

[2]. Mor, M., et al. Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands. Bioorganic & Medicinal Chemistry, 9(4), 1045–1057.

Chemical & Physical Properties

[ Density]:
1.172g/cm3

[ Boiling Point ]:
612.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀N₂O₂

[ Molecular Weight ]:
308.37

[ Flash Point ]:
324.2ºC

[ Exact Mass ]:
308.15200

[ PSA ]:
54.12000

[ LogP ]:
3.91300

[ Vapour Pressure ]:
6.16E-15mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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