TWS119 TFA

Names

[ Name ]:
TWS119 TFA

[Synonym ]:
MFCD18086896
Acetic acid, 2,2,2-trifluoro-, compd. with 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol (2:1)
3-{[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}phenol trifluoroacetate (1:2)
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate
MFCD09037535

Biological Activity

[Description]:

TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. HochstrasserRM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc NatlAcad Sci U S A. 2007 Sep 4;104(36):14190-6.

[2]. Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14190-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄N₄O_2.2CF₃CO₂H

[ Molecular Weight ]:
546.38

[ Exact Mass ]:
546.097412